Stress Model Mechanics (Paradigm Shift in Medical Expectations and Modeling)

COMPLEXITY, SYSTEMS AND NONLINEARITYSystems Modeling Autism Thresholds: Instead of Linear Single cause-effect rules of Koch’s Postulates and Disease Model of Medicine. Nonlinear impacts rely on thresholds from multiple inputs instead of linear models that look to average the impact as “the dose makes the poison”. Nonlinear models consider the context as what sets the poison: … Continue reading Stress Model Mechanics (Paradigm Shift in Medical Expectations and Modeling)

Outline of a Stress Model for Autism

A Stress Model for Autism HERITABLE SUSCEPTIBILITIES GeneticsMutation rates are increased with exposure to oxidative stress and mutations can increase risks to oxidative stress. Mutations are an attempt to regulate and balance stressBehavioral GeneticsSexual Dimorphism GeneticsGender Stress Genetics (Verma 2011)PROGRAMMING EpigeneticsTransgenerational Epigenetics and Ancestral Programming HPA AxisImmune ActivationDEFICIENCIES/IMBALANCES Microbiome Fatty Acid Sunlight Melatonin Vitamin D Nitric OxideENVIRONMENTAL CHEMICAL STRESSORS: … Continue reading Outline of a Stress Model for Autism

Linear Vs Nonlinear Toxicology

What Are Toxins? A toxin is typically thought of as skull and crossbones, something that can kill you.  A toxin has what is called an LD50, that is the amount that will kill half (50%) of the population of species it is exposed to. Toxins typically have a very specific mechanism of action unique to … Continue reading Linear Vs Nonlinear Toxicology

Is Autism a Stress Adaptation?

Could Autism be seen as a Stress Adaptation? Author: Lori Hogenkamp, B.A. Psychology Edited: July 24, 2018 Introduction On the cellular level, stress, or how the body-brain maintains homeostasis, is through complex physiological responses called allostasis (McEwen, 2017). These various stress coping strategies and trade-offs are quite individualistic, on both the social and cellular levels … Continue reading Is Autism a Stress Adaptation?

Original Paper: Autism, Stress and The Creative Brain

April 2009 Note: This was my original hypothesis paper (thought process). I started this journey with my own realization of my own autism. I knew that my own brain wasn't broken and seemed to be working in overdrive and I asked the question: What if these brains already had a unique way of processing information … Continue reading Original Paper: Autism, Stress and The Creative Brain

Suramin: A Stress Perspective of this Very Old Drug and Autism

This is a study to get really excited about.  Not only the potential (with funding) for drug possibilities, but its potential for uncovering aspects of underlying mechanism for autistic dysfunctioning. The drug, Suramin, is over 100 years old and was used for African Sleeping Sickness. Sleeping Sickness is a parasitic infection from the Tetse fly … Continue reading Suramin: A Stress Perspective of this Very Old Drug and Autism

Perfect Stress is not an Amount (Part 1)

In a PsychologyToday article entitled “The Perfect Amount of Stress” the author, Thea Singer, contemplates “when do we have too little stress and when do we have too much stress?” A good question, but likely an over-simplified one. A better question might be: “When have we been overly programmed by stress and when do the … Continue reading Perfect Stress is not an Amount (Part 1)