Outline of a Stress Model for Autism

A Stress Model for Autism

  1. HERITABLE SUSCEPTIBILITIES 
    1. Genetics
      1. Mutation rates are increased with exposure to oxidative stress and mutations can increase risks to oxidative stress. Mutations are an attempt to regulate and balance stress
    2. Behavioral Genetics
    3. Sexual Dimorphism Genetics
    4. Gender Stress Genetics (Verma 2011)
  2. PROGRAMMING 
    1. Epigenetics
    2. Transgenerational Epigenetics and Ancestral Programming
    3. HPA Axis
    4. Immune Activation
  3. DEFICIENCIES/IMBALANCES
    1. Microbiome
    2. Fatty Acid
    3. Sunlight
      1. Melatonin 
      2. Vitamin D 
      3. Nitric Oxide
  4. ENVIRONMENTAL CHEMICAL STRESSORS: Early Life Environment
    1. Maternal Stress: Pesticides, Endocrine Disruptors, Mitochondrial disturbance, Viruses, Infections, Pharmaceuticals, Chemicals, Metals, Trauma, Pollutants
  5. ENVIRONMENTAL SOCIAL AND PHYSICAL STRESSORS : Later Life Environment
    1. Lights, Sounds, Sensory 
    2. Physical and Mental Growth Stages and Hormone Changes 
    3. Social Expectations and Isolation
  6. VARIABLE OUTCOMES
    1. CORE Traits
    2. CORE Symptoms
      1. Atypical Sensory, RRBIs, Social and Communication disturbances
    3. Co-Occurring
      1. Interoception, Synethesia, ADHD, Dyslexia, Dyscalcia and Alexithymia, OCD, Tourrette’s,
    1. Co-morbid
      1. Affective disorders; Anxiety, depression, aggression,
      2. Seizures, Suicidiality, learning disorders, Digestive, Immune, Skin and Sensory Atypicality, Seizures, Metabolism, Circadian disturbances, Ehlers-Danlos, FMS/CFS, Autoimmunity, Digestive isssues

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