Outline of a Stress Model for Autism

A Stress Model for Autism

  1. HERITABLE SUSCEPTIBILITIES 
    1. Genetic
      1. Mutation rates are increased with exposure to oxidative stress and mutations can increase risks to oxidative stress. Mutations are an attempt to regulate and balance stress. 
      2. SIMPLEX Families and Autism
      3. COMPLEX Families and Autism
    2. Behavioral Genetics: Genetic Heritability of Peripheral Minds, Temperament and Thinking Types.
    3. Sexual Dimorphic Stress Impacts
      1. Word vs Pattern Thinkers 
      2. Estrogen vs Testosterone Brains
    4. Gender Stress Differences
  2. PROGRAMMING 
    1. Transgenerational Epigenetics and Ancestral Programming
    2. Prenatal Stress Programming
    3. Epigenetics
  3. DEFICIENCIES/IMBALANCES that Create Susceptibilities: 
    1. Microbiome
    2. Fatty Acid
    3. Sunlight
      1. Melatonin 
      2. Vitamin D 
      3. Nitric Oxide
  4. Cellular STRESS: Early Life Environment
    1. Maternal Stress: Pesticides, Endocrine Disruptors, Mitochondrial disturbance, Viruses, Infections, Pharmaceuticals, Chemicals, Metals, Trauma, Pollutants, Social Stress 
  5. Environmental STRESS : Later Life Environment: Hyper/hypo-sensitivity to stressors
    1. Lights, Sounds, Sensory 
    2. Physical and Mental Growth Stages and Hormone Changes 
    3. Social Expectations and Isolation
  6. VARIABLE OUTCOMES
    1. CORE Symptoms
      1. Atypical Sensory, RRBIs, Social and Communication disturbances
    2. Co-Occurring
      1. Interoception and Alexithymia
      2. Digestive, Immune, Skin and Sensory Atypicality, Seizures, Metabolism, Circadian disturbances
    3. Co-Morbids and Overlapping: Genetic and Environmental Stress
      1. Affective disorders; Anxiety, depression, aggression
      2. Schizophrenia, Bipolar, ADHD, PDA
      3. Ehlers-Danlos, FMS/CFS, Autoimmunity

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