Stress Model Mechanics (Paradigm Shift in Medical Expectations and Modeling)

COMPLEXITY, SYSTEMS AND NONLINEARITYSystems Modeling Autism Thresholds: Instead of Linear Single cause-effect rules of Koch’s Postulates and Disease Model of Medicine. Nonlinear impacts rely on thresholds from multiple inputs instead of linear models that look to average the impact as “the dose makes the poison”. Nonlinear models consider the context as what sets the poison: … Continue reading Stress Model Mechanics (Paradigm Shift in Medical Expectations and Modeling)

Outline of a Stress Model for Autism

A Stress Model for Autism HERITABLE SUSCEPTIBILITIES GeneticsMutation rates are increased with exposure to oxidative stress and mutations can increase risks to oxidative stress. Mutations are an attempt to regulate and balance stressBehavioral GeneticsSexual Dimorphism GeneticsGender Stress Genetics (Verma 2011)PROGRAMMING EpigeneticsTransgenerational Epigenetics and Ancestral Programming HPA AxisImmune ActivationDEFICIENCIES/IMBALANCES Microbiome Fatty Acid Sunlight Melatonin Vitamin D Nitric OxideENVIRONMENTAL CHEMICAL STRESSORS: … Continue reading Outline of a Stress Model for Autism